[Code of Federal Regulations]
[Title 21, Volume 3]
[Revised as of April 1, 2006]
From the U.S. Government Printing Office via GPO Access
TITLE 21--FOOD AND DRUGS
CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN
PART 184_DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS
SAFE--Table of Contents
Subpart B_Listing of Specific Substances Affirmed as GRAS
Sec. 184.1537 Nickel.
(a) Elemental nickel (CAS Reg. No. 7440-02-0) is obtained from
nickel ore by transforming it to nickel sulfide
(Ni3S2). The sulfide is roasted in air to give
nickel oxide (NiO). The oxide is then reduced with carbon to give
(b) The Food and Drug Administration is developing food-grade
specifications for nickel in cooperation with the National Academy of
Sciences. In the interim, this ingredient must be of a purity suitable
for its intended use.
(c) In accordance with Sec. 184.1(b)(1), the ingredient is used in
food with no limitation other than current good manufacturing practice.
The affirmation of this ingredient as generally recognized as safe
(GRAS) as a direct human food ingredient is based upon the following
current good manufacturing practice conditions of use:
(1) The ingredient is used as a catalyst as defined in Sec.
170.3(o)(24) of this chapter.
(2) The ingredient is used in the hydrogenation of fats and oils as
defined in Sec. 170.3(n)(12) of this chapter at levels not to exceed
current good manufacturing practice. Current good manufacturing practice
includes the removal of nickel from fats and oils following
(d) Prior sanctions for this ingredient different from the uses
established in this section do not exist or have been waived.
[48 FR 51618, Nov. 10, 1983]
Additives that reference this regulation:
Source: U.S. Code of Federal Regulations - CFR Title 21, Part 184, Section 1537
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