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176.300 Slimicides.

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[Code of Federal Regulations]
[Title 21, Volume 3]
[Revised as of April 1, 2006]
From the U.S. Government Printing Office via GPO Access
[CITE: 21CFR176.300]

[Page 232-233]
 
                        TITLE 21--FOOD AND DRUGS
 
CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN 
                          SERVICES (CONTINUED)
 
PART 176_INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS--Table 
of Contents
 
 Subpart B_Substances for Use Only as Components of Paper and Paperboard
 
Sec.  176.300  Slimicides.

    (a) Slimicides may be safely used in the manufacture of paper and 
paperboard that contact food, in accordance with the following 
prescribed conditions:
    (1) Slimicides are used as antimicrobial agents to control slime in 
the manufacture of paper and paperboard.
    (2) Subject to any prescribed limitations, slimicides are prepared 
from one or more of the slime-control substances named in paragraph (c) 
of this section to which may be added optional adjuvant substances as 
provided for under paragraph (d) of this section.
    (3) Slimicides are added to the process water used in the production 
of paper or paperboard, and the quantity added shall not exceed the 
amount necessary to accomplish the intended technical effect.
    (b) To insure safe usage, the label or labeling of slimicides shall 
bear adequate directions for use.
    (c) Slime-control substances permitted for use in the preparation of 
slimicides include substances subject to prior sanction or approval for 
such use and the following:

------------------------------------------------------------------------
           List of substances                      Limitations
------------------------------------------------------------------------
Acrolein...............................
Alkenyl (C16-C18) dimethylethyl-
 ammonium bromide.
n-Alkyl (C12-C18) dimethyl benzyl
 ammonium chloride.
1,2-Benzisothiazolin-3-one.............  At a level of 0.06 pound per
                                          ton of dry weight fiber.
Bis(1,4-bromoacetoxy)-2-butene.........
5,5-Bis(bromoacetoxymethyl) m-dioxane..
2,6-Bis(dimethylaminomethyl)
 cyclohexanone.
1,2-Bis(monobromoacetoxy) ethane [CA     At a maximum level of 0.10
 Reg. No. 3785-34-0].                     pound per ton of dry weight
                                          fiber.
Bis(trichloromethyl)sulfone............
4-Bromoacetoxymethyl-m-dioxolane.......
2-Bromo-4'-hydroxyacetophenone.........
2-Bromo-2-nitropropane-1,3-diol (CAS     At a maximum level of 0.6 pound
 Reg. No. 52-51-7).                       per ton of dry weight fiber.
[beta]-Bromo-[beta]-nitrostyrene.......  At a maximum level of 1 pound
                                          per ton of dry weight fiber.
Chloroethylenebisthiocyanate...........
5-Chloro-2 - methyl - 4 - isothiazolin-  At a level of 2.5 pounds per
 3-one calcium chloride and 2-methyl-4-   ton of dry weight fiber.
 isothiazolin-3-one calcium chloride
 mixture at a ratio of 3 parts to 1
 part.
Chlorinated levulinic acids............
Chloromethyl butanethiolsulfonate......
Cupric nitrate.........................
n-Dialkyl (C12-C18)
 benzylmethylammonium chloride.
1,2-Dibromo-2,4-dicyanobutane (CAS Reg.  At a maximum level of 0.005% of
 No. 35691-65-7).                         dry weight fiber.
2,2-Dibromo-3-nitrilopropionamide......  At a maximum level of 0.1 lb/
                                          ton of dry weight fiber.
2,3-Dibromopropionaldehyde.............
4,5-dichloro-1, 2-dithiol-3-one (CAS     For use only at levels not to
 Reg. No. 1192-52-5).                     exceed 10 milligrams per
                                          kilogram in the pulp slurry.

[[Page 233]]


1,3-Dihalo-5,5-dimethylhydantoin (where  At a maximum level of 1.0
 the dihalo (halogen) may be bromine      kilogram (kg) per 1,000 kg of
 and/or chlorine) that may contain no     dry weight fiber.
 more than 20 weight percent 1,3-dihalo-
 5-ethyl-5-methylhydantoin (where the
 dihalo (halogen) may be bromine and/or
 chlorine)..
4-(Diiodomethylsulfonyl) toluene (CAS    At a maximum level of 0.2 pound
 Reg. No. 20018-09-1)..                   per ton (100 grams/1,000
                                          kilograms) of dry weight
                                          fiber.
3,5-Dimethyl 1,3,5,2H-
 tetrahydrothiadiazine-2-thione.
Dipotassium and disodium
 ethylenebis(dithiocarba-mate).
Disodium cyanodithioimidocarbonate.....
n-Dodecylguanidine hydrochloride.......  At a maximum level of 0.20
                                          pound per ton of dry weight
                                          fiber.
Glutaraldehyde (CAS Reg. No. 111-30-8).
2-(p-hydroxyphenyl) glyoxylohydroximoyl  At a level of 0.02 pound per
 chloride (CAS Registry No. 34911-46-1).  ton of dry weight fiber.
2-Hydroxypropyl methanethiol sulfonate.
2-Mercaptobenzothiazole................
Methylenebisbutanethiolsulfonate.......
Methylenebisthiocyanate................
2-Nitrobutyl bromoacetate [CA Reg. No.   At a maximum level of 0.15
 32815-96-6].                             pound per ton of dry weight
                                          fiber.
N-[[alpha]-(Nitroethyl)benzyl]
 ethylenediamine.
Potassium 2-mercaptobenzothiazole......
Potassium N-hydroxymethyl-N-
 methyldithiocarba-mate.
Potassium N-methyldithiocarbamate......
Potassium pentachlorophenate...........
Potassium trichlorophenate.............
Silver fluoride........................  Limit of addition to process
                                          water not to exceed 0.024
                                          pound, calculated as silver
                                          fluoride, per ton of paper
                                          produced.
Silver nitrate.........................
Sodium dimethyldithiocarbamate.........
Sodium 2-mercaptobenzothiazole.........
Sodium pentachlorophenate..............
Sodium trichlorophenate................
1,3,6,8-Tetraazatricyclo[6.2.1.13,6]
 dodecane.
3,3,4,4-Tetrachlorotetrahydrothiophene-
 1,1-dioxide.
Tetrakis(hydroxymethyl)phosphonium       Maximum use level of 84 mg/kg
 sulfate (CAS Reg. No. 55566-30-8).       in the pulp slurry. The
                                          additive may also be added to
                                          water, which when introduced
                                          into the pulp slurry, results
                                          in a concentration in the pulp
                                          slurry not to exceed 84 mg/kg.
2-(Thiocyanomethylthio) benzothiazole..
Vinylene bisthiocyanate................
------------------------------------------------------------------------

    (d) Adjuvant substances permitted to be used in the preparation of 
slimicides include substances generally recognized as safe for use in 
food, substances generally recognized as safe for use in paper and 
paperboard, substances permitted to be used in paper and paperboard by 
other regulations in this chapter, and the following:

Acetone.
Butlylene oxide.
Dibutyl phthalate.
Didecyl phthalate.
N,N-Dimethylformamide.
Dodecyl phthalate.
Ethanolamine.
Ethylene glycol.
Ethylenediamine.
N-methyl-2-pyrrolidone (CAS Reg. No. 872-50-4).
a,a'-[Methylenebis[4-(1,1,3,3-tetra methyl butyl)-o-phenylene]] 
bis[omega-hydroxypoly (oxyethylene)] having 6-7.5 moles of ethylene 
oxide per hydroxyl group.
Monomethyl ethers of mono-, di-, and tri propyl ene glycol.
Nonylphenol reaction product with 9 to 12 molecules of ethylene oxide.
Octylphenol reaction product with 25 molecules of propylene oxide and 40 
molecules of ethylene oxide.

[42 FR 14554, Mar. 15, 1977, as amended at 42 FR 41854, Aug. 19, 1977; 
44 FR 75627, Dec. 21, 1979; 46 FR 36129, July 14, 1981; 49 FR 5748, Feb. 
15, 1984; 51 FR 19059, May 27, 1986; 51 FR 43734, Dec. 4, 1986; 54 FR 
18103, Apr. 27, 1989; 55 FR 31825, Aug. 6, 1990; 64 FR 46130, Aug. 24, 
1999; 64 FR 69900, Dec. 15, 1999; 65 FR 40497, June 30, 2000; 65 FR 
70790, Nov. 28, 2000; 69 FR 24512, May 4, 2004]





Additives that reference this regulation:


Source: U.S. Code of Federal Regulations - CFR Title 21, Part 176, Section 300


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